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KMID : 1059519900340010076
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Journal of the Korean Chemical Society
1990 Volume.34 No. 1 p.76 ~ p.84
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Optical Resolution of Dansyl Amino acids by Xylenyl-L-proline Copper (Ⅱ) Complex
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Lee Sun-Haing
Oh Tae-Sub
Park Bun-Ja
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Abstract
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Optical isomers of dansyl amino acids were separated by a chiral mobile phase addition method. Two metha and para isomers of xylenyl-L-proline were prepared and used as the ligands of copper(Ⅱ) chelate to resolve the dansyl amino acids. Their elution behaviors were similar to those obtained from the addition of copper (Ⅱ) benzyl-L-proline chelate. The matrix effect of the mobile phase such as pH, concentration of buffer and compositions of organic solvent acetonitrile affected the optical resolution. The separation mechanism could be explained by a cis-trans effect of the ligand exchange reaction and hydrophobic interaction between the ternary complex and the stationary phase.
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